Genome Announcements Collection 1: Ciliovirus, Brinovirus; Marine RNA Viruses SF-1, SF-2, SF-3; Leviviridae RNA Phages EC and MBGenome Announcements, 2015
Widespread Recombination, Reassortment, and Transmission of Unbalanced Compound Viral Genotypes in Natural Arenavirus InfectionsPLoS, 2015
Destructin-1 is a Collagen-Degrading Endopeptidase Secreted by P. destructans, the Causative Agent of White-Nose SyndromePNAS, 2015
Genome-wide regulatory dynamics of translation in the Plasmodium falciparum asexual blood stageseLife, 2014
SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of PlasmodiumPNAS, 2014
A chemical rescue screen identifies a P.falcip. apicoplast inhibitor targeting MEP isoprenoid precursor biosynthesisAAC, 2014
Actionable Diagnosis of Neuroleptospirosis by Next-Generation SequencingNEJM, 2014
Arenaviruses are one of the largest families of human hemorrhagic fever viruses and are known to infect both mammals and snakes. Arenaviruses package a large (L) and small (S) genome segment in their virions. For segmented RNA viruses like these, novel genotypes can be generated through mutation, recombination, and reassortment. Although it is believed that an ancient recombination event led to the emergence of a new lineage of mammalian arenaviruses, neither recombination nor reassortment has been definitively documented in natural arenavirus infections. Here, we used metagenomic sequencing to survey the viral diversity present in captive arenavirus-infected snakes. Check out the paper at PLoS Pathogen for the full story. Read the paper here.
iBiology Talk by Joseph DeRisi: Genome Sequencing for Pathogen Discovery
For decades, a strange neurological disease has plagued snakes around the world. The snakes tie themselves into knots, exhibit strange behaviors, and eventually die. In this talk, Dr. Joseph DeRisi describes how his lab uncovered the mysterious agent responsible for this disease, which turned out to be an ancient arenavirus.
Watch the Full Talk Here