 The 3A protein from multiple picornaviruses utilizes the Golgi Adaptor Protein ACBD3 to Recruit PI4KIIIβ Journal of Virology, 2012
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 Plate-based transfection and culturing technique for genetic manipulation of Plasmodium falciparum Malaria Journal 2012
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 Chemical Rescue of Malaria Parasites Lacking an Apicoplast Defines Organelle Function in Blood-Stage P.falciparum PLoS Biology 2011
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 Temporal Analysis of the Honey Bee Microbiome Reveals Four Novel Viruses and Seasonal Prevalence of Known Viruses, Nosema, and Crithidia PLoS ONE. 2011
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 Transcriptome Sequencing Demonstrates that Human Papillomavirus Is Not Active in Cutaneous Squamous Cell Carcinoma. J Invest Dermatol. 2011
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 Viral Infection in Acute Exacerbation of Idiopathic Pulmonary Fibrosis Am. J. Respir. Crit. Care Med. 2011
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 RNA-Seq analysis of splicing in P.falciparum uncovers new splice junctions, alternative splicing and splicing of antisense transcripts Nuc. Acids Res. 2010
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|  Malaria caused by Plasmodium spp parasites is a profound human health problem that has shaped our evolutionary past and continues to influence modern day with a disease burden that disproportionately affects the world's poorest and youngest. A plastid organelle, the apicoplast, has been hailed as Plasmodium's ?Achilles' heel? because it contains bacteria-derived pathways that have no counterpart in the human host and therefore may be ideal drug targets. In this study, we use a simple chemical method to generate parasites that have lost their apicoplast, normally a deadly event, but which survive??rescued? by the addition of an essential metabolite to the culture. This chemical rescue demonstrates that the apicoplast serves only a single essential function, namely isoprenoid precursor biosynthesis during blood-stage growth, validating this metabolic function as a viable drug target. Moreover, the apicoplast-minus Plasmodium strains generated in this study will be a powerful tool for identifying apicoplast-targeted drugs and as a potential vaccine strain with significant advantages over current vaccine technologies. Read the Full Press Release Here |
 A 10-month study of healthy honey bees by University of California, San Francisco scientists has identified four new viruses that infect bees, while revealing that each of the viruses or bacteria previously linked to colony collapse is present in healthy hives as well.
The study followed 20 colonies in a commercial bee-keeping operation of more than 70,000 hives as they traversed the country pollinating crops, to answer one basic question: what does a normal hive look like in terms of viruses and bacteria through the seasons?
To View Press Release |
 We are pleased to release PRICE (Paired-Read Iterative Contig Extension), a de novo genome assembler implemented in C++. Its name describes the strategy that it implements for genome assembly: PRICE uses paired-read information to iteratively increase the size of pre-assembled contigs. It was designed to address the challenge of assembling viral genomes that constituted a small minority of the reads within ultra-deep, short-read, metagenomic, shotgun datasets. PRICE has already enabled the discovery of several novel virus genomes from such complex datasets, and it is also being applied to the de novo assembly of large individual genomes. It is provided here as a beta release, pre-publication. Download PRICE (beta) |
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