Abstract:
In the yeast Saccharomyces cerevisiae, meiotic recombination is initiated by double-strand DNA breaks (DSBs). Meiotic DSBs occur at relatively high frequencies in some genomic regions (hotspots), and relatively low frequencies in others (coldspots). We used DNA microarrays to estimate variation in the level of nearby meiotic DSBs for all 6200 yeast genes. Hotspots were non-randomly associated with regions of high G+C base composition and certain transcriptional profiles. Coldspots were non-randomly associated with the centromeres and telomeres.
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