Figure 2: Hotspot activity of yeast ORFs. To estimate DSB formation adjacent to each ORF, we measured the ratio of hybridization to a DSB-enriched probe (P2) to a total genomic probe (P1) in seven microarrays. The log of the median hybridization ratio for each of the 6200 ORFs is graphed; ratios were grouped into bins of 0.015 log units. An arrow marks the separation between the ORFs with hybridization ratios ranked in the top-eighth from those in the bottom seven-eighths.

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