Serological evidence of human klassevirus infection
Greninger AL, Holtz L, Kang G, Ganem D, Wang D, Derisi JLClin Vaccine Immunol. 2010Abstract:
Klassevirus is a proposed new genus of picornavirus that has been associated with pediatric diarrhea. In this study, we used recombinant klassevirus 3C protease as the capture antigen for an indirect serological ELISA. Four of six klassevirus RT-PCR-positive individuals demonstrated seroconversion against the 3C protease, suggesting that klassevirus infection and replication occur in humans. Additional screening of 353 samples from an age-banded serological cohort from two St. Louis hospitals indicated a seroprevalence of 6.8%.