While children were largely spared during the SARS-CoV-2 pandemic, Multisystem inflammatory syndrome in children (MIS-C) is one of the enduring mysteries of the early years of COVID. MIS-C manifests as a severe post-COVID inflammatory syndrome affecting multiple organ systems and often requires extreme measures of life support. Despite numerous investigations, the underlying drivers of MIS-C for the majority of cases remained unclear.

In close collaboration with numerous laboratories and clinicians across the country, including the Chan Zuckerberg Biohub SF , Baylor, Univ. of Mississippi, Emory, Univ of Alabama at Birmingham, Univ. of Pennsylvania, Nicklaus Children’s Hospital, Univ. of North Carolina Chapel Hill, Univ. of Utah, Arkansas Children’s Hospital, Cincinnati Children’s Hospital, Indiana University, Children’s Mercy Kansas City, Vanderbilt, Cooperman Barnabas Medical Center, Univ. of South Carolina Charleston, Univ. of Colorado, the CDC, St. Jude Children’s Hospital, and UCSF, we report a significant breakthrough that sheds light on the origins of this severe disease.


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