The Plasmodium falciparum cytoplasmic translation apparatus: a promising therapeutic target not yet exploited by clinically approved anti-malarialsChristine Moore Sheridan , Valentina E. Garcia , Vida Ahyong and Joseph L. DeRisi
Malaria Journal, 2018Abstract: The continued spectre of resistance to existing anti-malarials necessitates the pursuit of novel targets
and mechanisms of action for drug development. One class of promising targets consists of the 80S ribosome and
its associated components comprising the parasite translational apparatus. Development of translation-targeting
therapeutics requires a greater understanding of protein synthesis and its regulation in the malaria parasite. Research
in this area has been limited by the lack of appropriate experimental methods, particularly a direct measure of parasite
translation.
