Whole-genome sequencing rule-out of suspected hospital-onset Rhizopus outbreaks
Victoria T. Chu Open the ORCID record for Victoria T. Chu[Opens in a new window] , Saba Nafees Open the ORCID record for Saba Nafees[Opens in a new window] , Eric Waltari Open the ORCID record for Eric Waltari[Opens in a new window] , Nicole McNeil Open the ORCID record for Nicole McNeil[Opens in a new window] , Carolyn Caughell , Estella Sanchez-Guerrero , Lusha Wang , Kim Stanley , Gail Cunningham , Joan Wong Open the ORCID record for Joan Wong[Opens in a new window] , Maíra Phelps , Cristina M. Tato , Steve Miller , Joseph L. DeRisi , Deborah S. Yokoe , Lynn Ramirez-Avila and Charles R. Langelier

Cambridge University Press, 2023

Abstract: Two independent temporal-spatial clusters of hospital-onset Rhizopus infections were evaluated using whole-genome sequencing (WGS). Phylogenetic analysis confirmed that isolates within each cluster were unrelated despite epidemiological suspicion of outbreaks. The ITS1 region alone was insufficient for accurate analysis. WGS has utility for rapid rule-out of suspected nosocomial Rhizopus outbreaks.