Successful Treatment of Balamuthia mandrillaris Granulomatous Amebic Encephalitis with NitroxolineNatasha Spottiswoode, Douglas Pet, Annie Kim, Katherine Gruenberg, Maulik Shah, Amrutha Ramachandran, Matthew T Laurie, Maham Zia, Camille Fouassier, Christine L Boutros, Rufei Lu, Yueyuan Zhang, Venice Servellita, Andrew Bollen, Charles Y Chiu, Michael R Wilson, Liza Valdivia, Joseph L DeRisi
Emerging Infectious Diseases, 2023Abstract: A patient in California, USA, with rare and usually fatal Balamuthia mandrillaris granulomatous amebic encephalitis survived after receiving treatment with a regimen that included the repurposed drug nitroxoline. Nitroxoline, which is a quinolone typically used to treat urinary tract infections, was identified in a screen for drugs with amebicidal activity against Balamuthia.
