BIV-Spectrin Autoantibodies in 2 Individuals With Neuropathy of Possible Paraneoplastic Origin: A Case SeriesChristopher M. Bartley, MD,* Thomas T. Ngo, BS,* Bonny D. Alvarenga, BA, Andrew F. Kung, BA, Lindsay H. Teliska, BS, Michael Sy, MD, Joseph L. DeRisi, PhD, Matthew N. Rasband, PhD, Sean J. Pittock, MD, Divyanshu Dubey, MBBS, Michael R. Wilson, MD, MAS, and Samuel J. Pleasure, MD, PhD
Neurology Journals, 2022Abstract: Objective- To identify the autoantigen in 2 individuals with possible seronegative paraneoplastic neuropathy.
Methods- Serum and CSF were screened by tissue-based assay and panned for candidate autoantibodies by phage display immunoprecipitation sequencing (PhIP-Seq). The candidate antigen was validated by immunostaining knockout tissue and HEK 293T cell-based assay.
