Lower respiratory tract infections in children requiring mechanical ventilation: a multicentre prospective surveillance study incorporating airway metagenomicsAlexandra Tsitsiklis, Christina M Osborne, Jack Kamm, Kayla Williamson, Katrina Kalantar, Gytis Dudas, Saharai Caldera, Amy Lyden, Michelle Tan, Norma Neff, Victoria Soesanto, J Kirk Harris, Lilliam Ambroggio, Aline B Maddux, Todd C Carpenter, Ron W Reeder, Chris Locandro, Eric A F Simões, Matthew K Leroue, Mark W Hall, Athena F Zuppa, Joseph Carcillo, Kathleen L Meert, Anil Sapru, Murray M Pollack, Patrick S McQuillen, Daniel A Notterman, J Michael Dean, Matt S Zinter, Brandie D Wagner, Joseph L DeRisi, Peter M Mourani*, Charles R Langelier
The Lancet Microbe, 2022Abstract: Lower respiratory tract infections (LRTI) are a leading cause of critical illness and mortality in mechanically
ventilated children; however, the pathogenic microbes frequently remain unknown. We combined traditional diagnostics with metagenomic next generation sequencing (mNGS) to evaluate the cause of LRTI in critically ill children.
