![](webicons/eranmickpic.jpg) Integrated host/microbe metagenomics enables accurate lower respiratory tract infection diagnosis in critically ill children JCI, 2023
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![](webicons/aaronb1.jpg) Autoantigen profiling reveals a shared post-COVID signature in fully recovered and long COVID patients JCI Insight, 2023
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![](webicons/schromj.jpg) Field assessment of BinaxNOW antigen tests as COVID-19 treatment entry point at a community testing site in San Francisco during evolving omicron surges PLOS One, 2023
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![](webicons/maderapic1.jpg) Prolonged silent carriage, genomic virulence potential and transmission between staff and patients characterize a neonatal intensive care unit (NICU) outbreak of methicillin-resistant Staphylococcus aureus (MRSA) Cambridge University Press, 2023
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![](webicons/greenhouse1.jpg) Antibodies to repeat-containing antigens in Plasmodium falciparum are exposure-dependent and short-lived in children in natural malaria infections eLife, 2023
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![](webicons/pittock2.jpg) Dual ankyrinG and subpial autoantibodies in a man with well-controlled HIV infection with steroid-responsive meningoencephalitis: A case report Frontiers, 2023
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![](webicons/cchiupic.jpg) Successful Treatment of Balamuthia mandrillaris Granulomatous Amebic Encephalitis with Nitroxoline Emerging Infectious Diseases, 2023
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| ![](module_pictures/WebsiteBanner.jpg) Actionable Diagnosis of Neuroleptospirosis by Next-Generation Sequencing
A 14-year-old boy with severe combined immunodeficiency presented 3 times to a medical facility over 4 months with fever and headache that progressed to hydrocephalus and status epilepticus necessitating a medically-induced coma after starting empiric steroids for a suspected autoimmune condition. An exhaustive diagnostic workup including brain biopsy was unrevealing. In collaboration with Dr. Charles Chiu’s lab (UCSF Department of Laboratory Medicine), unbiased next-generation sequencing of the patient’s cerebrospinal fluid and computational analysis of the results using an ultra-rapid bioinformatics pipeline for comprehensive pathogen detection identified 475 sequence reads out of 3,063,784 (0.016%) corresponding to Leptospira spp. This result was obtained within 48 hours of sample receipt. The patient responded dramatically when treated with appropriate antimicrobials and discontinuation of steroids, and was discharged home 24 days later near his premorbid baseline.
[ Read the Article in the New York Times ] •
[ Press Release ] |
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